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    Vol 1(1), 2014
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  • Know Res., 2014, 1(1),  pp 40-49  

    DOI:10.7598/kor2014.111

    Research Article

    Synthesis, Characterization and Antimicrobial Activity of Some Isothiocyanato Complexes of Dioxotungsten(VI) Containing Mannich Base Ligands

  • Mohita Sharma
  • College of Engineering, School of biotechnology, Shri Mata Vaishno Devi University, Katra-182320, Jammu-182320, India
  • Abstract

    Six isothiocyanato complexes of dioxotungsten(VI) with the compositions [WO2(NCS)2L-L] (where L-L = Morpholino-benzyl benzamide (MBB), piperidinobenzyl benzamide (PBB), piperidinobenzyl urea (PBU), Morpholinobenzyl urea (MBU), piperidinobenzyl thiourea (PBTU) and morpholinobenzyl thiourea (MBTU)) are presented. The complexes have been prepared by the reaction of tetraisothiocyanatodioxotungsten(VI) anion with corresponding ligands in aqueous medium in presence of HCl. These have been characterized by elemental analysis, conductance and magnetic susceptibility measurements, IR spectra, electronic spectra, TGA/DTA, 1H NMR and mass studies. Studies revealed that these complexes are non-electrolytes and diamagnetic in nature. The ligands are bound to metal in a bidentate mode through carbonyl oxygen/thiocabonyl sulphur and the heterocyclic ring nitrogen. Finally, the free ligands and their metal complexes were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties. The energy-minimized structures of these complexes have been obtained by molecular modeling using Hyperchem release 8.0.

    Keywords

    Tetraisothiocyanatodioxotungsten(VI), Mannich base

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