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  • Know Res., 2015, 2(1),  pp 19-23  

    DOI:10.7598/kor2015.130

    Research Article

    Utility of Hydrazide in Synthesis of Some Novel Heterocyclic Compounds and Evaluation as Antidepressant Potency

  • RASHA E. EL-MEKAWY
  • Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Al Mukarrama, Saudi Arabia /
    Department of Petrochemicals, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt
  • Abstract

    This work demonstrates a rapid, efficient method for synthesis of some new heterocyclic compounds viz. 2-(3-(p-tolylsulfonyl)phenyl -5-phenyl-amino)1,3,4-thiadiazole (6), 2-(3-(p-tolylsulfonyl)phenyl -5-phenylamino) 1,3,4-oxadiazole (7) and 2-(3-(p-tolylsulfonyl) phenyl -5-mercapto)1,3,4-triazole (8). These compounds exhibits highest antidepressant activity.

    Keywords

    1,3,4-Oxadiazole, Hydrazine hydrate, Antidepressant

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